Disabling enzyme allows mice to gorge without becoming obese, new study finds
Researchers at the University of California, Berkeley, have identified a new enzyme that plays a far more important role than expected in controlling the breakdown of fat. In a new study to be published Jan. 11 in the journal Nature Medicine, researchers report that mice that have had this enzyme disabled remained lean despite eating a high-fat diet and losing a hormone that suppresses appetite.
“We have discovered a new enzyme within fat cells that is a key regulator of fat metabolism and body weight, making it a promising target in the search for a treatment for human obesity,” said Hei Sook Sul, UC Berkeley professor of nutritional sciences and toxicology and principal investigator of the research.
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