Eating Less May Not Extend Human Life: Caloric Restriction May Benefit Only Obese Mice
ScienceDaily (Jan. 26, 2009) — If you are a mouse on the chubby side, then eating less may help you live longer.
For lean mice – and possibly for lean humans, the authors of a new study predict – the anti-aging strategy known as caloric restriction may be a pointless, frustrating and even dangerous exercise.
“Today there are a lot of very healthy people who look like skeletons because they bought into this,” said Raj Sohal, professor at the University of Southern California’s School of Pharmacy.
He and Michael Forster, of the University of North Texas Health Science Center, compared the life span and caloric intake of two genetically engineered strains of mice.
The “fat” strain, known as C57BL/6, roughly doubles in weight over its adult life. That strain benefited from caloric restriction, Sohal said.
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